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Ivica Olic netted the opener on 11 minutes. Ivan Perisic had put the Croats two up with a superb solo goal just after the break.
Mario Mandzukic hit a brace, scoring on 61 and 73 minutes.
Croatia collected three points after two matches and hold third place in the Group. Croatia will face Mexico in next match. Cameroon lost all chances to advance to last 16.