Stay up to date with the latest news
Subscribe to our telegram channel
Luis Suarez scored the only goal of the game in the 43 minute, which allowed Uruguay to top Group A.
Mexico also progressed to the last 16 due to a superior goal difference to hosts South Africa.
In the second match of the Group, hosts South Africa beat France 2-1.
Bongani Khumalo and Katlego Mphela scored for South Africa, while substitute Florent Malouda converted Franck Ribery's pass on 70 minutes.