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Ahmadjon Musaev’s side, who already booked spot in the last 16, conceded a goal on 38 minutes. Gino Acevedo scored the goal.
Nicolas Lopez doubled the lead of South Americans two minutes after restart.
Giorgian de Arrascaeta netted the third goal of the match, while Ruben Bentancourt scored the fourth goal of Uruguay on 77 minutes.
In the result, Uzbekistan took the third place in the Group and will face either Greece or Columbia in the last 16.