The draw takes place at 4pm Malaysia time at the AFC House in Kuala Lumpur.
The draw for the continent’s second-tier club tournament, the AFC Cup 2010, takes place at 3pm.
The 2010 ACL will be the second edition of the revamped competition, in which only the leagues and clubs that fulfil strict criteria in relation to professionalism are included in the 32-club draw.
The clubs are drawn into eight groups of four teams, with four groups featuring teams from West and Central Asia, while the other four are populated by clubs from East Asia and the Asean region.
The top two teams from each group advance to the Round of 16.
The AFC Cup also features 32 teams divided into eight groups of four with the top two progressing to the last 16.
The identity of both the ACL 2010 and AFC Cup 2010 teams will be announced soon, AFC said.