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Lokomotiv, vice-champions of last season, met with Metallurg. The match ended with the score 0-0.
Bunyodkor recorded a 2-0 victory over Bukhara at home thanks to goals of Zuagi and Gofurov. Nasaf defeated Andijan with the score 3-1. Artur Gevorkyan recorded a brace for Nasaf in the match.
Kyzylkum claimed a 4-1 win over Sogdiana, while debutants Qoqand-1912 stunned Dinamo Samarkand with 1-0 victory.
Navbakhor lost to Mashal with the score 2-0 at home, while Neftchi and Shortan shared spoils after 1-1 draw.